ALTERATIONS OF ARTERIOLAR REACTIVITY IN A RAT POLYCYSTIC OVARY SYNDROME MODEL EFFECTS OF PARALLEL VITAMIN D3 ADMINISTRATION PhD thesis

Alterations of Arteriolar Reactivity in a Rat Polycystic Ovary Syndrome Model - Effects of Parallel Vitamin D3 Administration

Arteriolar biomechanics in a rat polycystic ovary syndrome model - effects of parallel vitamin D3 treatment.

UNLABELLED To clarify the effects of dihydrotestosterone (DHT)-induced polycystic ovary syndrome (PCOS) on arteriolar biomechanics in a rat model and the possible modulatory role of vitamin D3. METHODS AND RESULTS The PCOS model was induced in female Wistar rats by ten-weeks DHT treatment. Arteriolar biomechanics was tested in arterioles by pressure arteriography in control as well as DHT- an...

Effect of Vitamin D3 on Mitochondrial Biogenesis in Granulosa Cells Derived from Polycystic Ovary Syndrome

Background: Polycystic ovary syndrome (PCOS) is an endocrine disorder diagnosed by anovulation hyperandrogenism.Hyperandrogenism increases apoptosis, which will eventually disturb follicular growth in PCOS patients.Since mitochondria regulate apoptosis, they might be affected by high incidence of follicular atresia. This may causeinfertility. Since vitamin D3 has been shown to...

Vascular reactivity changes in a polycystic ovary syndrome rat model and the effect of vitamin D3

Protective Effect of Hydroethanolic Extract of Lippia citrodora L. Leaf and Vitamin D3 on Estradiol Valerate-Induced Polycystic Ovary Syndrome in Mice

Background and Objectives: This study was conducted to investigate the protective effect of hydroethanolic extract of Lippia citrodora L. leaf (LCE) and vitamin D3 on polycystic ovary syndrome (PCOS) in suri rats.   Methods: This experimental study was performed on 48 female suri rats with a weight range of 25-35g. The subjects were divided into 8 groups (n=6 each), namely control (food + wate...